Table 1.

O-linked N-acetylglucosamine signalling in immune cells

Cells	Effects of O-GlcNAc modification
T cells	PMA/ionomycin or ConA treatment leads to an increase in O-GlcNAc glycoproteins (Kearse & Hart, 1991) Tissue-specific deletion of OGT in T cells leads to reduced numbers of total CD4+ T cells, but does not affect the development of CD4/CD8 thymocytes (O'Donnell et al, 2004) TCR stimulation leads to O-GlcNAc modification of transcription factors NF-κB and NFAT, and is required for T-cell activation (Golks et al, 2007)
B cells	BCR stimulation leads to O-GlcNAc modification of transcription factors NF-κB and NFAT, and is required for B-cell activation (Golks et al, 2007)
Neutrophils	Chemokine stimulation leads to an increase in O-GlcNAc (Kneass & Marchase, 2004) Neutrophil signalling and motility is dependent on O-GlcNAc cycling (Kneass & Marchase, 2005)

BCR, B-cell receptor; ConA, concanavalin A; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factor-κB; O-GlcNAc, O-linked N-acetylglucosamine; OGT, O-linked N-acetylglucosaminyltransferase; PMA, phorbol 12-myristate 13-acetate; TCR, T-cell receptor.