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. 2008 Jul 11;9(8):721–724. doi: 10.1038/embor.2008.130

Figure 1.

Figure 1

Embryonic compensation versus adult specificity. (A) Forkhead box A1 (FOXA1) and FOXA2 show overlapping and compensatory activation of the pancreatic transcription factor PDX1 expression during embryonic development of the pancreas. Loss of PDX1 expression and the development of mice lacking a pancreas require the ablation of both FOXA1 and FOXA2. (B) By contrast, FOXA2 alone exhibits specific biological functions in the adult endocrine pancreas and regulates a transcription network of genes in mature β-cells.