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Forkhead factors working towards a common goal. Both forkhead box F1 (FOXF1) and FOXF2 are required for normal embryonic development and integrity of the intestine. FOXF1 and FOXF2 act by distinct and non-overlapping mechanisms, and together maintain intestinal epithelial integrity by promoting extracellular matrix (ECM) production through inhibition of Wingless 5a (WNT5a). In the absence of FOXF2, specific layers of the gut disintegrate. BMP4, bone morphogenetic protein 4.
