Figure 2.

Representation of the two NF-κB signaling pathways. Classical signaling (depicted left) is activated by TNFα, IL1β or LPS. Activation of canonical signaling depends on the IKK holocomplex (IKKα, IKKβ, IKKγ/NEMO). Activated IKK phosphorylates IκBs, leading to the proteasomal degradation and subsequent nuclear translocation of classical NF-κB. An alternative signaling pathway (depicted right) is activated by lymphotoxin, CD40L or BAFF. Signaling depends on IKKα and leads to the nuclear translocation of a p52/RelB dimer.