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. Author manuscript; available in PMC: 2008 Aug 13.
Published in final edited form as: Curr Stem Cell Res Ther. 2008 May;3(2):99–106. doi: 10.2174/157488808784223050

Fig. (3). LIFR/gp130 receptor complex signal transduction pathways and how s-SHIP may impact them in pluripotent stem cells.

Fig. (3)

Although s-SHIP does not become phosphorylated after LIF stimulation, s-SHIP is constitutively present at the membrane and thus can impact the signaling pathways downstream of ES cell receptors. Adapted from illustrations by Desponts et al. [6] and Burdon et al. [76].