Figure 2.

Schematic shows the activation and propagation of the extrinsic coagulation pathway and fibrinolysis, as well as the sites of action for tissue factor pathway inhibitor (TFPI), activated protein C (APC), thrombomodulin (TM), antithrombin, heparins, and the pulmonary formulation of tissue plasminogen activator (pf-tPA). PAI-1 = plasminogen activator inhibitor-1; TAFI = thrombin-activated fibrinolysis inhibitor; FDP = fibrin degradation products. (Adapted from references 4-8.)