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. 2008 Aug 14;118(9):3087–3097. doi: 10.1172/JCI35781

Figure 3. Hsp104 prevents A30P α-syn–induced neurodegeneration.

Figure 3

(A–G) Degenerating nigral neurons were detected by silver staining. (A and D) Noninjected sides did not show any specific silver staining. (D–G) Higher magnification reveals numerous silver-positive dark structures in the substantia nigra of animals expressing A30P/YFP (E). (G) Abundant neuritic pathology clearly showed the presence of degenerating neurites. (C and F) Coexpression of Hsp104 with A30P α-syn prevents the appearance of silver-positive degenerating neurons. Scale bar: 300 μm (A–C); 100 μm (D–G).