Scheme 3. Synthesis of alkyl substituted analogs.
a) n-BuLi, THF, −78°C (b) H2, 10%Pd/C, 9% AcOH/EtOH (c) Cs2CO3, BrCH2CO2R3, DMF, then NaOH, MeOH (d) K2CO3, DMF, p-NO2PhOTf (e) PdCl2(dppf), R4MgCl (f) TBAF, THF.
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