. Author manuscript; available in PMC: 2008 Aug 13.

Published in final edited form as: J Am Chem Soc. 2006 Jul 12;128(27):8868–8874. doi: 10.1021/ja060760v

Table 2.

Summary of activities on three consensus promotors.

TRE	Receptor	T3, nM (% efficacy)	QH2, nM (% efficacy)	GC-1, nM (% efficacy)
DR4	TRα	0.12±0.03 (100)	737±59.0 (90)	6.2±1.6 (88)
	TRβ	0.51±0.05 (100)	341±25 (98)	2.1±0.9 (90)
	TRβ(H435A)	392±84 (97)	6.43±0.57 (93)	>5000 (40)

F2	TRα	0.25±0.08 (100)	1596±84 (76)	n.d.
	TRβ	0.86±0.11 (100)	1240±122 (58)	n.d.
	TRβ(H435A)	774±53 (82)	27.9±7.1 (93)	n.d.

Pal	TRα	0.12±0.04 (100)	1439±142 (75)	n.d.
	TRβ	0.44±0.05 (100)	594±37 (87)	n.d.
	TRβ (H435A)	747±119 (90)	22.9±5.9 (93)	n.d.

% efficacy: maximum inducible activity compared to TR(wt) with T3. n.d.: not determined