Table 4.

Predictors of All-Cause Mortality Among Olmsted County, MN, Residents FIrst Diagnosed With Paget's Disease of Bone in 1950–1994

Variable	Hazard ratio (95% CI)	p
Univariate model
Age at diagnosis per 10-yr increase	2.36 (1.98–2.82)	<0.001
Year of diagnosis per 10-yr increase	1.28 (1.08–1.51)	0.004
Year of diagnosis, July 1974 or after	1.48 (1.06–2.06)	0.022
Male	1.44 (1.06–1.97)	0.020
AlkPhos high, within 2 years of diagnosis	1.12 (0.77–1.64)	0.538
Symptoms at presentation	0.69 (0.50–0.94)	0.021
Hearing loss before or within 6 mo after dx	1.44 (0.97–2.12)	0.068
Pagetic involvement of spine	1.33 (0.97–1.81)	0.074
Pagetic involvement of skull	1.31 (0.84–2.06)	0.238
Pagetic involvement of pelvis	1.24 (0.89–1.72)	0.198
Pagetic involvement of femur	1.24 (0.89–1.72)	0.208
Monostotic vs. polyostotic	1.40 (0.98–1.99)	0.063
Hip or knee replacement	1.95 (1.27–3.00)	0.002
Fracture of pagetic bone	1.22 (0.70–2.12)	0.478
Multivariate model
Age at diagnosis per 10-yr increase	2.50 (2.08–3.02)	<0.001
Male	1.68 (1.22–2.30)	0.001