Table 3.
Summary table change from baseline (average of all four courses)
| 4 h | 24 h | |||||||
|---|---|---|---|---|---|---|---|---|
| Change | 95%-Confidence interval | P value | Change | 95%-Confidence interval | P value | |||
| Lower | Upper | Lower | Upper | |||||
| ANP (pmol/L) | 38.1% | −0.3% | 91.3% | 0.05 | 44.3% | 3.6% | 101.2% | 0.03 |
| CK-MB mass (mg/L) | −2.2% | −18.6% | 17.6% | 0.80 | 26.1% | 4.4% | 52.2% | 0.02 |
| NT-proBNP (ng/L) | 18.0% | −14.6% | 63.0% | 0.30 | 237.9% | 149.4% | 357.8% | <0.001 |
| HR (bpm) | −0.29 | −3.37 | 2.79 | 0.85 | 1.46 | −1.67 | 4.60 | 0.34 |
| QT (ms) | 10.95 | 3.91 | 17.98 | 0.004 | 10.96 | 3.77 | 18.15 | 0.005 |
| QTc Bazett (ms) | 10.79 | 4.70 | 16.88 | 0.002 | 15.82 | 9.66 | 21.97 | <0.001 |
| QTc linear (ms) | 10.04 | 5.39 | 14.69 | <0.001 | 13.13 | 8.40 | 17.85 | <0.001 |
Average change (for all four courses) from baseline, 95%-confidence intervals and P values (for the biochemical markers results represent percentage change, for ECG parameters results are shown in absolute changes)
ANP atrial natriuretic peptide, CK-MB creatine kinase isoenzyme MB, NT-proBNP N-terminal pro brain natriuretic peptide, HR heartrate, QT QT-interval, QTc Bazett QT interval corrected according to Bazett, QTc linear QT interval corrected according to Framingham’s linear correction method
Averages are estimated, as MIXED model analysis was used to correct for predose and missing values