Table 7. Conservation of quantitative trait nucleotides.

Gene	SNP	LRT P-value	Phenotype	Reference
ASP1	D142H	7.9E-10	Acetic acid production	Marullo et al. 2007
CYS4	I123N	3.9E-09	Multi-drug sensitivity	Kim and Fay 2007
END3	S258N	NA	High temperature growth	Sinha et al. 2006
GPA1	S469I	9.7E-09	Cell elongation, gene regulation	Yvert et al. 2003; Nogami et al. 2007
MKT1	G30D	2.5E-08	Sporulation efficiency, High temperature growth	Deutschbauer et al. 2005; Sinha et al. 2006
MLH1	D761G	4.5E-07	Mismatch repair	Heck et al. 2006
PHO84	L259P	3.2E-08	Drug sensitivity	Perlstein et al. 2007
PMS1	R818K	1.1E-06	Mismatch repair	Heck et al. 2006
TAO3	E1493Q	2.9E-06	Sporulation efficiency	Deutschbauer et al. 2005
RAS2	A[-9]-	NA	Sporulation efficiency	Ben-Ari et al. 2006
RME1	-[-308]A	NA	Sporulation efficiency	Deutschbauer et al. 2005

LRT P-value is from alignments of distantly related homologs, no distant homologs were identified for the END3 SNP. Promoter polymorphisms are indicated by position relative to the start codon in brackets, dash indicates deletion. The likelihood ratio test is not applicable to InDels.