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. Author manuscript; available in PMC: 2008 Aug 14.
Published in final edited form as: J Am Chem Soc. 2006 Jun 14;128(23):7463–7465. doi: 10.1021/ja0618954

Scheme 2.

Scheme 2

Reagents. a. 1. 7a, NiCl2, CrCl2, 86%. 2. Ac2O, Py. 93%, 3. Pd(OAc)2, CaCO3, 97%. b. 1. TFA, H2O, CH2Cl2, 91%, 2. Ac2O, Py. 99%. 3. TFA, H2O, CH2Cl2, 93%. 4. CH(OMe)3, PPTS. 5. K2CO3, MeOH. 6. TBSCl, DMAP, 98% over 3 steps. 7. DIBAL, 82%. 8. MeI, DEAD, PPh3, 88%.