TABLE 2.
Haplotype-based association analysis in Western breeds
| Haplotype frequencyb
|
||||||
|---|---|---|---|---|---|---|
| Haplotypea | Normal | PPD | Odds ratio (C.I. of 95%)c | χ2 (1) | P-valued | Pc valuee |
| 1-CCCAGC | 0.250 | 0.727 | 8.00 (2.76 23.22) | 20.95 | 4.60 × 10−6 | 2.30 × 10−5 |
| 2-CCCAAC | 0.125 | 0.000 | 5.88 | 0.015 | 0.075 | |
| 3-TCCCAC | 0.312 | 0.068 | 6.21 (1.54 25.11) | 8.71 | 0.0032 | 0.016 |
| 4-TCCCGC | 0.250 | 0.137 | 2.11 (0.74 6.33) | 1.88 | 0.17 | |
| 5-CTTAGT | 0.063 | 0.068 | 1.09 (0.21 5.80) | 0.01 | 0.91 | |
a
The SNPs used to construct haplotypes are Int16, Int15, Int6, ZRSi5, ShotR2, and Int3, whose positions on the canine genome are designated in supplemental Table 6S.
b
Individuals were selected from nine breeds, including 24 normal (10 homozygous and 14 heterozygous) and 22 PPD dogs (10 homozygous and 12 heterozygous).
c
C.I. denotes the confidence interval.
d
The P-values for the genotype level association with haplotype 1 are 6.27 × 10−6 (χ2 = 20.40) and 1.31 × 10−2 (χ2 = 6.15) for dominant and recessive modes of inheritance, respectively.
e
The P-values were corrected by multiplying the number of haplotypes.