TABLE 2.
dN/dS
|
Relaxed branch-site test P | Strict branch-site test P | ||||||
---|---|---|---|---|---|---|---|---|
Gene | Length (codons) | Na | Sa | Background | Foreground (human) | Empirical P | ||
ASPM | 3477 | 17 | 7 | 0.109 | 5.455 | 0.553 | 0.473 | 0.027 |
BLZF1 | 400 | 3 | 0 | 0.146 | 999b | 0.084 | 0.260 | 0.105 |
CDX1 | 265 | 2 | 0 | 0.104 | 999 | 0.292 | 0.307 | 0.125 |
CDX4 | 284 | 4 | 0 | 0.358 | 999 | 0.027 | 0.120 | 0.031 |
CITED2 | 270 | 2 | 0 | 0.038 | 999 | 0.028 | 0.426 | 0.124 |
DMRT3 | 472 | 11 | 3 | 0.084 | 0.859 | 0.005 | 0.489 | 0.037 |
EHF | 300 | 1 | 0 | 0.048 | 313 | 0.139 | 0.471 | 0.102 |
ELK4 | 431 | 2 | 0 | 0.270 | 999 | 0.092 | 0.212 | 0.042 |
FOXI1 | 378 | 5 | 3 | 0.083 | 0.332 | 0.481 | 0.811 | 0.277 |
FOXJ2 | 574 | 2 | 0 | 0.099 | 75.8 | 0.025 | 0.239 | 0.085 |
GBX2 | 348 | 1 | 0 | 0.014 | 999 | 0.050 | 0.531 | 0.255 |
HESX1 | 185 | 1 | 0 | 0.269 | 999 | 0.186 | 0.429 | 0.180 |
HOXA5 | 270 | 2 | 1 | 0.029 | 0.445 | 0.095 | 1.000 | 0.833 |
HOXD4 | 255 | 2 | 0 | 0.082 | 999 | 0.021 | 0.288 | 0.076 |
KLF10 | 390 | 2 | 0 | 0.164 | 999 | 0.039 | 0.229 | 0.090 |
MCPH1 | 740 | 9 | 4 | 0.112 | 1.000 | 0.315 | 1.000 | 0.748 |
MEOX1 | 254 | 2 | 0 | 0.127 | 999 | 0.075 | 0.298 | 0.185 |
NR2C1 | 603 | 4 | 0 | 0.089 | 999 | 0.008 | 0.192 | 0.309 |
NR3C2 | 984 | 5 | 1 | 0.102 | 0.770 | 0.026 | 0.318 | 0.069 |
PEG3 | 1590 | 8 | 3 | 0.232 | 0.944 | 0.067 | 0.803 | 0.177 |
PGR | 933 | 9 | 4 | 0.197 | 0.893 | 0.072 | 0.469 | 0.029 |
RBM9 | 367 | 2 | 0 | 0.400 | 999 | 0.410 | 0.184 | 0.041 |
SCML1 | 208 | 2 | 0 | 1.279 | 999 | 0.446 | 0.231 | 0.075 |
SOHLH2 | 425 | 10 | 0 | 0.484 | 999 | 0.011 | 0.023 | <0.001 |
T | 435 | 2 | 0 | 0.052 | 999 | 0.068 | 0.318 | 0.124 |
TAF11 | 211 | 2 | 0 | 0.138 | 999 | 0.031 | 0.234 | 0.034 |
ZFP37 | 630 | 9 | 0 | 0.237 | 999 | 0.011 | 0.032 | <0.001 |
ZNF192 | 578 | 4 | 1 | 0.210 | 1.605 | 0.270 | 0.411 | 0.101 |
Substitutions between the inferred human–chimpanzee ancestor and the human sequence. N, nonsynonymous; S, synonymous.
Values of 999 for dN/dS indicate dS = 0, so dN/dS is undefined. Values in italics reflect P < 0.05.