TABLE 5.
Dependence of population-attributable risk (PAR) on SNP frequencies in three studies of type II diabetes (Scott et al. 2007; Sladek et al. 2007; Zeggini et al. 2007)
| SNP | Source | pcontrol | pcase | PAR |
|---|---|---|---|---|
| rs1801282 | Scott et al. (2007) | 0.823 | 0.848 | 0.16447 |
| rs4402960 | Scott et al. (2007) | 0.304 | 0.341 | 0.056146 |
| rs7754840 | Scott et al. (2007) | 0.36 | 0.387 | 0.044046 |
| rs13266634 | Scott et al. (2007) | 0.609 | 0.649 | 0.11396 |
| rs10811661 | Scott et al. (2007) | 0.85 | 0.872 | 0.17187 |
| rs1111875 | Scott et al. (2007) | 0.522 | 0.546 | 0.052863 |
| rs7903146 | Scott et al. (2007) | 0.181 | 0.227 | 0.059508 |
| rs5219 | Scott et al. (2007) | 0.464 | 0.489 | 0.048924 |
| rs9300039 | Scott et al. (2007) | 0.892 | 0.924 | 0.42105 |
| rs8050136 | Scott et al. (2007) | 0.381 | 0.406 | 0.042088 |
| rs7923837 | Sladek et al. (2007) | 0.623 | 0.665 | 0.11141 |
| rs7480010 | Sladek et al. (2007) | 0.301 | 0.336 | 0.050072 |
| rs3740878 | Sladek et al. (2007) | 0.728 | 0.76 | 0.11765 |
| rs11037909 | Sladek et al. (2007) | 0.729 | 0.76 | 0.11439 |
| rs1094369 | Zeggini et al. (2007) | 0.319 | 0.361 | 0.060957 |
Data from Scott et al. are from their Table S1; data from Sladek et al. are from their Table 1; data from Zeggini et al. are from their Table S2. When the same SNP was found in two or more studies, data from only one study were used. PAR is computed using Equation 4 in the text, with pcase = pC and pcontrol = p.