Table 1.
Variable | Human soluble insulin (12 IU) | Insulin lispro (12 U) | Ultra-fast insulin (12 IU) | Ultra-fast insulin (6 IU) | Ultra-fast insulin (3 IU) |
---|---|---|---|---|---|
Pharmacokinetic | |||||
tC max+50% (min) | 37 ± 22 | 26 ± 10 | 18 ± 18 | 7 ± 3 | 12 ± 13 |
tC max (min) | 120 ± 70a | 66 ± 34a | 60 ± 43a | 51 ± 48 | 54 ± 44 |
tC max−50% (min) | 260 ± 105a | 170 ± 39a | 181 ± 76a | 145 ± 59 | 126 ± 44 |
C max (pmol/l) | 209 ± 51 | 437 ± 98 | 325 ± 142b | 204 ± 71b | 111 ± 33b |
AUCINS 0–120 min ([nmol/l] × min) | 13.8 ± 3.2 | 36.2 ± 7.9 | 26.9 ± 9.6b | 17.3 ± 4.6b | 9.0 ± 2.9b |
AUCINS 0–480 min ([nmol/l] × min) | 46.3 ± 15.2 | 68.4 ± 16.4 | 52.9 ± 14.8b | 30.8 ± 8.4b | 16.1 ± 6.5b |
Pharmacodynamic | |||||
tGIRmax+50% (min) | 66 ± 15c | 51 ± 13c | 33 ± 17c | 35 ± 17 | 31 ± 14 |
tGIRmax (min) | 193 ± 57d | 152 ± 30d | 136 ± 56d | 115 ± 32 | 111 ± 41 |
tGIRmax−50% (min) | 357 ± 67 | 295 ± 54 | 280 ± 60 | 270 ± 72 | 297 ± 113 |
GIRmax (mg kg−1 min−1) | 10.4 ± 3.3 | 11.9 ± 2.5 | 11.5 ± 2.6e | 9.1 ± 2.9e | 6.5 ± 3.0e |
AUCGIR 0–120 min (mg/kg) | 580 ± 164f | 781 ± 174f | 915 ± 301f,e | 718 ± 255e | 524 ± 262e |
AUCGIR 0–480 min (mg/kg) | 2993 ± 1045 | 2977 ± 753 | 2991 ± 709e | 2223 ± 717e | 1597 ± 848e |
To convert GIR in mg kg–1 min–1 to μmol kg–1 min–1 multiply by 5.5 To convert AUCGIR in mg/kg to mmol/kg multiply by 5.5
aHuman soluble insulin>insulin lispro, ultra-fast insulin
b12 IU>6 IU>3 IU
cHuman soluble insulin>insulin lispro>ultra-fast insulin
dHuman soluble insulin>insulin lispro>ultra-fast insulin
e12 IU>6 IU>3 IU
fInsulin lispro, ultra-fast insulin>human soluble insulin