TABLE 4.
Risk of transition from a given transient state (intact cognition, mild cognitive impairments, or global impairment) to dementia or death in the Nun Study, United States, 1991–2002 (1,905 transitions in 470 subjects)
| Characteristic | Dementia |
Death |
||
|---|---|---|---|---|
| OR* | 95% CI* | OR | 95% CI | |
| Transition from intact cognition | ||||
| Age (years) | 1.13 | 0.93, 1.37 | 1.11 | 1.02, 1.22 |
| Education | ||||
| ≤High school | 41.48 | 4.00, 42.40 | 1.24 | 0.15, 10.2 |
| Undergraduate degree | 2.07 | 0.28, 15.10 | 0.92 | 0.42, 2.01 |
| Graduate degree | 1.00 | Reference | 1.00 | Reference |
| Apolipoprotein E *E4 allele | ||||
| Present | 9.43 | 1.27, 69.90 | 2.58 | 1.06, 6.28 |
| Absent | 1.00 | Reference | 1.00 | Reference |
| Transition from mild cognitive impairments | ||||
| Age (years) | 1.07 | 1.02, 1.12 | 1.07 | 1.02, 1.12 |
| Education | ||||
| ≤High school | 1.11 | 0.49, 2.53 | 1.38 | 0.64, 2.97 |
| Undergraduate degree | 0.76 | 0.45, 1.29 | 0.92 | 0.55, 1.52 |
| Graduate degree | 1.00 | Reference | 1.00 | Reference |
| Apolipoprotein E *E4 allele | ||||
| Present | 1.12 | 0.60, 2.08 | 1.10 | 0.60, 2.00 |
| Absent | 1.00 | Reference | 1.00 | Reference |
| Transition from global impairment | ||||
| Age (years) | 1.05 | 0.99, 1.11 | 1.03 | 0.97, 1.00 |
| Education | ||||
| ≤High school | 0.61 | 0.23, 1.59 | 0.44 | 0.19, 1.02 |
| Undergraduate degree | 1.00 | 0.50, 2.00 | 0.56 | 0.30, 1.06 |
| Graduate degree | 1.00 | Reference | 1.00 | Reference |
| Apolipoprotein E *E4 allele | ||||
| Present | 2.32 | 1.17, 4.58 | 0.92 | 0.45, 1.88 |
| Absent | 1.00 | Reference | 1.00 | Reference |
*
OR, odds ratio; CI, confidence interval.