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. 2008 Aug 11;105(32):11299–11304. doi: 10.1073/pnas.0801457105

Fig. 2.

Fig. 2.

Up-regulation of marker proteins in organs and plasma of aging telomere-dysfunctional mice. (A–F) The histograms show the mRNA expression of the indicated biomarker relative to GAPDH in the indicated organs. The analysis was conducted on 2-, 12-, and 24-month-old mTerc+/+ mice and on 2- and 12-month-old G4mTerc−/− mice (n = 5 mice per group). The bars show mean values. Error bars show standard deviation. (G) The dot plots show the expression of the marker proteins and chitinase enzyme activity in plasma of 2-, 12-, and 24-month-old mTerc+/+ mice, and of 2- and 12-month-old G4mTerc−/− mice (n = 5 mice per group). The lines show mean values.