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Proposed mechanism for tumorcidal actions of pharmacological ascorbate. Ascorbate (AA) distributes from the blood to the tumor extracellular fluid compartments after i.v. administration. In the tumor interstitium, ascorbate is oxidized to ascorbate radical (AA•) by a metalloprotein catalyst (M), which donates an electron (e−) to oxygen forming superoxide radical (O2−) and ultimately the tumorcidal effector H2O2. In blood, these reactions are minimized (4, 5).
