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. 2008 Jul 1;4:199. doi: 10.1038/msb.2008.36

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Copyright © 2008, EMBO and Nature Publishing Group

This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits distribution and reproduction in any medium, provided the original author and source are credited. Creation of derivative works is permitted but the resulting work may be distributed only under the same or similar licence to this one. This licence does not permit commercial exploitation without specific permission.

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Identification of genes mediating HGF-induced cellular transition to migration. (A) Workflow of data analysis, inverse modeling and experimental validation. (B) Histogram of rank scores for all 20 188 measured genes after HGF stimulation (cf. Materials and methods). The ranks numbered 1–20 correspond to the 20 highest ranked genes (cf. gene list in (C)). (C) Top: mean and peak fold expression of the 20 top-ranked genes upon HGF stimulation. Bottom: expression of the same genes upon FGF-7 stimulation. Data points were normalized to the maximal mean and peak fold expression of the respective experiments (cf. Materials and methods).