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. Author manuscript; available in PMC: 2008 Aug 14.
Published in final edited form as: Org Lett. 2006 Aug 17;8(17):3667–3670. doi: 10.1021/ol061173h

Table 1.

Mukaiyama Aldol Survey

graphic file with name nihms-58242-t0005.jpg
entry Lewis acid equiv temp (°C) solvent dr
1 MgBr2·OEt2 2.0 −20 CH2Cl2 4 : 1
2 MgBr2·OEt2 2.0 −78 to −20 CH2Cl2 4.5 : 1
3 BF3·OEt2 1.1 −78 CH2Cl2 5 : 1
4 TiCl3(OiPr) 1.0 −78 PhCH3 5 : 1
5 TiCl2(OiPr)2 1.0 −78 PhCH3 32 : 1a
6 TiCl2(OiPr)2 2.0 −78 PhCH3 37 : 1b
7 TiCl2(OiPr)2 2.5 −78 PhCH3 41 : 1c
a

40% of 16 recovered.

b

10% of 16 recovered.

c

95% of 17 isolated.