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. Author manuscript; available in PMC: 2008 Dec 1.
Published in final edited form as: Development. 2008 May 14;135(12):2161–2172. doi: 10.1242/dev.017459

Figure 5. Epidermal differentiation fails in activated β-catenin mutants.

Figure 5

(A–N) Expression of KRT14 (A, B), DSC1 (I, J) and DSG1 (K, L) is decreased and expression of KRT10, filaggrin and loricrin (C – H) is absent in stabilized β-catenin mutants, but laminin α5 expression (M, N) indicates that the basement membrane remains intact. Size bar in (N) applies to (A – N). (O – S) TEM of E16.5 control (O, R) and mutant (P, Q, S) dorsal epidermis (O – Q) or epidermal-dermal junction region (R, S) reveals presence of basal (Ba), spinous (Sp) and granular (Gr) layers in control epidermis (O) and their absence in the mutant (P). Pigment granules are present in mutant ectoderm (red arrows in Q). The basement membrane (BM) is intact in the mutant, but hemidesmosomes (red arrows in (R)) are reduced in number (S).