| Table 1A: Selected genes upregulated in activated β-catenin mutant epidermis at E15.5 |
| Wnt/β-catenin pathway |
Lef1, Tcf4, Nkd1, Nkd2, Dkk4, Dact1, Wif1, Axin2, Krm1, Wisp1, Wnt5a, Wnt11, Wnt10a
|
| Non-canonical Wnt pathway |
Daam2, Prickle2, Vangl2, Ror2, Wnt5a, Wnt11
|
| SHH pathway |
Shh, Ptch1, Ptch2, Smo, Gli3 |
| BMP pathway |
Bmp2, Bmp4, Msx1, Msx2
|
| Notch pathway |
Hey1, Hes6, Deltex-1, Dll1
|
| Axon guidance |
Sema4c, Sema3c, Unc5b, Unc5c
|
| Neuronal |
Robo1, Netrin G1
|
| Melanoblast regulatory |
Adamts20, Kitl |
| Melanoblast / melanocyte expressed |
Mlana, Mitf, Mc1r
|
| Pigment deposition |
Foxn1 |
| Hair shaft precursor-associated |
S100a3, Mt4, Bmp2, Bmp4, Msx1, Msx2, Hoxc13, Foxq1, Foxn1
|
| Buttonhead family transcription factors |
Sp5, Sp8 |
| Hair shaft keratins |
Krt31, Krt32, Krt33a, Krt34, Krt35, Krt82, Krt85, mHa3 |
| Hair shaft keratin associated proteins |
Krtap16 family |
| Keratins specific for IRS cuticle |
Krt72, Krt73, Krt26 |
| Keratins expressed in IRS cuticle and other IRS layers |
Krt25, Krt27, Krt71 |
| Table 1B: Selected genes downregulated in activated β-catenin mutant epidermis at E15.5 |
| Gata3 regulated genes |
Gata3, Ptgs1, Sgpp1
|
| Signaling molecules |
Wnt7a, Tgfbr3
|
| Homeobox containing transcription factors |
Hoxa3, Hoxa5 and Hoxa7, Irx1, Irx2
|
| Stem cell-associated |
Lrig1, Krt15 |
| Epidermal stratification |
Krt14, Krt1, Krt10, Lor, Casp14, Clca1, Clca2, Hrnr
|
| Desmosomal components |
Dsc1, Dsc3, Dsg1 |
