Table III.
Association between ERCC1 and ERCC2/XPD genotypes and DNA adduct levels
| SNP | DNA adducts (RAL × 107) |
Crude OR (95% CI) | Adjusted ORa (95% CI) | Pb | |
| >27, no. (%) | ≤27, no. (%) | ||||
| All participants | 347 (49.1) | 360 (51.0) | |||
| ERCC2/XPD, g.18123137A>C, rs13181 | |||||
| AA | 133 (38.3) | 156 (43.3) | Reference | Reference | |
| AC | 166 (47.8) | 164 (45.6) | 1.19 (0.87–1.63) | 1.18 (0.86–1.63) | |
| CC | 48 (13.8) | 40 (11.1) | 1.41 (0.87–2.27) | 1.39 (0.86–2.26) | 0.312 |
| ERCC2/XPD, g.18135477G>A, rs1799793 | |||||
| GG | 131 (37.8) | 159 (44.2) | Reference | Reference | |
| GA | 171 (49.3) | 164 (45.6) | 1.27 (0.92–1.73) | 1.21 (0.88–1.66) | |
| AA | 45 (13.0) | 37 (10.3) | 1.48 (0.90–2.42) | 1.44 (0.87–2.38) | 0.183 |
| ERCC2/XPD, g.18120142C>A, rs238406 | |||||
| CC | 117 (33.7) | 90 (25.0) | Reference | Reference | |
| CA | 169 (48.7) | 197 (54.7) | 0.66 (0.47–0.93) | 0.63 (0.45–0.89) | |
| AA | 61 (17.6) | 73 (20.3) | 0.64 (0.42–1.00) | 0.64 (0.41–0.99) | 0.039 |
| ERCC1, g.18180954G>T, rs3212986 | |||||
| GG | 182 (52.6) | 217 (60.3) | Reference | Reference | |
| TG | 133 (38.4) | 124 (34.4) | 1.28 (0.93–1.75) | 1.27 (0.92–1.74) | |
| TT | 31 (9.0) | 19 (5.3) | 1.95 (1.06–3.56) | 1.89 (1.03–3.48) | 0.050 |
| ERCC1, g.18191871T>C, rs11615 | |||||
| TT | 131 (38.0) | 143 (39.7) | Reference | Reference | |
| CT | 151 (43.8) | 173 (48.1) | 0.95 (0.69–1.32) | 0.95 (0.68–1.31) | |
| CC | 63 (18.3) | 44 (12.2) | 1.56 (0.99–2.46) | 1.51 (0.95–2.38) | 0.079 |
a
OR adjusted for age, sex, smoking status, alcohol consumption and family history of cancer.
b
P value was obtained using the omnibus χ2 test with two degrees of freedom.