Table IV.
Association between ERCC1 and ERCC2/XPD genotypes and DNA adduct levels (RAL × 107) in never and ever smokers
| SNP | Never smokers |
Ever smokers |
Pa | ORb | ||||
| >27, no. (%) | ≤27, no. (%) | OR (95% CI) | >27, no. (%) | ≤27, no. (%) | OR (95% CI) | |||
| Totalc | 143 (43.2) | 188 (56.8) | 204 (54.3) | 172 (45.2) | ||||
| ERCC2/XPD, g.18123137A>C, rs13181 | ||||||||
| AA | 57 (39.9) | 80 (42.6) | Reference | 76 (37.3) | 76 (44.2) | Reference | Reference | |
| AC | 62 (43.4) | 91 (48.4) | 0.96 (0.60–1.53) | 104 (51.0) | 73 (42.4) | 1.42 (0.92–2.20) | 0.222 | 1.18 (0.86–1.63) |
| CC | 24 (16.8) | 17 (9.0) | 1.98 (0.98–4.02) | 24 (11.8) | 23 (13.4) | 1.04 (0.54–2.01) | 0.192 | 1.40 (0.87–2.26) |
| ERCC2/XPD, g.18135477G>A, rs1799793 | ||||||||
| GG | 63 (44.1) | 89 (47.3) | Reference | 68 (33.3) | 70 (40.7) | Reference | Reference | |
| GA | 60 (42.0) | 79 (42.0) | 1.07 (0.67–1.71) | 111 (54.4) | 85 (49.4) | 1.34 (0.87–2.08) | 0.489 | 1.21 (0.88–1.66) |
| AA | 20 (14.0) | 20 (10.6) | 1.41 (0.70–2.84) | 25 (12.3) | 17 (9.9) | 1.51 (0.75–3.05) | 0.891 | 1.46 (0.89–2.40) |
| ERCC2/XPD, g.18120142C>A, rs238406 | ||||||||
| CC | 56 (39.2) | 47 (25.0) | Reference | 61 (29.9) | 43 (25.0) | Reference | Reference | |
| CA | 55 (38.5) | 105 (55.9) | 0.44 (0.26–0.73) | 114 (55.9) | 92 (53.5) | 0.87 (0.54–1.41) | 0.052 | 0.63 (0.45–0.90) |
| AA | 32 (22.4) | 36 (19.1) | 0.75 (0.40–1.38) | 29 (14.2) | 37 (21.5) | 0.55 (0.30–1.03) | 0.501 | 0.64 (0.42–1.00) |
| ERCC1, g.18180954G>T, rs3212986 | ||||||||
| GG | 75 (52.4) | 113 (60.1) | Reference | 107 (52.7) | 104 (60.5) | Reference | Reference | |
| TG | 58 (40.6) | 65 (34.6) | 1.34 (0.85–2.13) | 75 (36.9) | 59 (34.3) | 1.24 (0.80–1.91) | 0.794 | 1.29 (0.94–1.76) |
| TT | 10 (7.0) | 10 (5.3) | 1.51 (0.60–3.80) | 21 (10.3) | 9 (5.2) | 2.27 (0.99–5.18) | 0.517 | 1.91 (1.04–3.51) |
| ERCC1, g.18191871T>C, rs11615 | ||||||||
| TT | 51 (35.7) | 80 (42.6) | Reference | 80 (39.6) | 63 (36.6) | Reference | Reference | |
| CT | 67 (46.9) | 88 (46.8) | 1.19 (0.74–1.92) | 84 (41.6) | 85 (49.4) | 0.78 (0.50–1.22) | 0.197 | 0.95 (0.69–1.32) |
| CC | 25 (17.5) | 20 (10.6) | 1.96 (0.99–3.89) | 38 (18.8) | 24 (14.0) | 1.25 (0.68–2.29) | 0.332 | 1.52 (0.96–2.39) |
a
P value is the homogeneity test of the OR between never and ever smokers.
b
OR is the estimated common OR from the Cochran–Mantel–Haenszel test.
c
Total is the subgroup sample size. Former smokers had one missing value for ERCC1 rs3212986 and two missing values for rs11615.