Table V.
Association between ERCC1 and ERCC2/XPD haplotypes and DNA adduct levels
| Haplotypes | DNA adducts (RAL × 107) |
OR (95% CI) | ORa (95% CI) | Pb | |
| >27, no. (%) | ≤27, no. (%) | ||||
| ERCC2/XPD, g.18123137A>C, rs13181; g.18135477G>A, rs1799793; g.18120142C>A, rs238406 | |||||
| AGA | 247 (37.14) | 291 (42.56) | Reference | Reference | |
| CAC | 197 (29.57) | 157 (22.93) | 1.56 (1.17–2.07) | 1.54 (1.16–2.05) | |
| CGA | 125 (18.84) | 108 (15.73) | 1.43 (1.04–1.98) | 1.48 (1.06–2.06) | |
| CGC | 34 (5.17) | 51 (7.47) | 0.78 (0.49–1.26) | 0.80 (0.49–1.29) | |
| CAA | 29 (4.29) | 42 (6.07) | 0.80 (0.46–1.38) | 0.77 (0.44–1.33) | |
| Otherc | 33 (4.96) | 36 (5.21) | 1.19 (0.75–1.90) | 1.13 (0.70–1.82) | 0.011 |
| ERCC1, g.18180954G>T, rs3212986; g.18191871T>C, rs11615 | |||||
| GT | 396 (57.46) | 451 (62.98) | Reference | Reference | |
| TC | 176 (25.54) | 154 (21.50) | 1.29 (1.00–1.66) | 1.29 (1.00–1.66) | |
| GC | 100 (14.52) | 105 (14.66) | 1.09 (0.81–1.48) | 1.07 (0.79–1.45) | |
| Otherc | 17 (2.46) | 6 (0.83) | 2.83 (1.14–7.04) | 2.79 (1.13–6.92) | 0.019 |
| ERCC1 and ERCC2/XPD combined | |||||
| AGAGT | 188 (31.02) | 231 (37.09) | Reference | Reference | |
| CGAGT | 83 (13.73) | 84 (13.46) | 1.23 (0.85–1.79) | 1.29 (0.88–1.89) | |
| CACTC | 104 (17.17) | 82 (13.25) | 1.65 (1.14–2.40) | 1.66 (1.14–2.42) | |
| CACGT | 50 (8.34) | 42 (6.82) | 1.49 (0.94–2.38) | 1.48 (0.92–2.36) | |
| Otherc | 180 (29.71) | 183 (29.34) | 1.28 (0.93–1.74) | 1.25 (0.91–1.72) | 0.111 |
a
Adjusted for age, sex, smoking status, alcohol consumption and family history of cancer.
b
P values were calculated with use of the omnibus χ2 test.
c
Other haplotypes with frequency less than 5%.