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Ka values for [3H]DAMGE binding to membrane preparations from P7 and adult rats treated with buprenorphine. Rats were given injections of buprenorphine as described for Figs. 1 and 2. [3H]DAMGE Kd estimations were obtained from 12-point homologous competition binding assays. Note that P7 control Ka values were consistently higher than the Kd values for buprenorphine-treated rats. Results are from six or seven separate experiments.
