Table 2.
Onset of expression of receptors and function-specific markers during mouse embryogenesis (see text for references). Expression analysed by in situ hybridization (ISH), immunohistochemistry (IHC) or detection of GFP expression from gene locus (GFP)
| Receptor/marker | Embryonic day (method) |
|---|---|
| Dorsal root ganglia | |
| ret | <E11.5 (ISH/IHC)a |
| GFRalpha1 | <E13 (ISH) |
| GFRalpha2 | <E13 (ISH)a |
| GFRalpha3 | <E13 (ISH) |
| TRPV1 | E13.5 (IHC) |
| TRPM8 | E16.5 (ISH/IHC) |
| Sympathetic ganglia | |
| ret | <E11.5 (GFP)b |
| GFRalpha1 | <E12.5 (ISH)c |
| GFRalpha2 | <E12.5 (ISH)b |
| GFRalpha3 | <E12.5 (ISH)b |
| ChAT | E10.5 (ISH)a,b |
| VAChT | E10.5 (ISH)a,b |
<Onset not precisely known; positive cells found at times indicated
aPostnatal increase in population size
bInitially widely expressed; embryonic downregulation to neuronal subpopulation
cAfter initial expression, completely downregulated during embryogenesis