Table 3.

Management of diarrhea and skin rash

When diarrhea occurs	When diarrhea resolves
Primary care
Use an anti-diarrheal therapy (e.g., loperamide)	Reintroduce deferasirox at a lower dose and gradually escalate
If necessary, reduce dose of deferasirox by half (by 10 mg/kg)
If diarrhea persists, take deferasirox at night

When rash occurs	When rash resolves
Mild to moderate
Rash often resolves spontaneously
Deferasirox may be continued without dose adjustment	Reintroduce deferasirox at 10 mg/kg (half dose) with or without low-dose prednisolone and gradually escalate
Severe
Interrupt deferasirox if necessary
Initiate prednisolone