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. Author manuscript; available in PMC: 2009 Jul 15.
Published in final edited form as: Free Radic Biol Med. 2008 Apr 15;45(2):193–200. doi: 10.1016/j.freeradbiomed.2008.04.003

Figure 1. Operant task in both mouse strains.

Figure 1

At the age of ~16 months, the control mice quickly learned to transition from FR1 to FR20 schedule of milk reward (WT), but the MsrA−/− mice lagged significantly behind the WT mice in learning to perform under these conditions (despite the fact that they were not different when the task demand was FR1). WT, n=7; MsrA−/−, n=8. Over the 32 training sessions shown in Fig. 1, the mean number of training sessions to reach FR20 was 10.9 for the WT mice and 30.6 for the MsrA−/− mice, t13=6.14, p<0.001(t13 refers to a “between-groups” t-test with 13 degrees of freedom).