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. Author manuscript; available in PMC: 2008 Aug 15.

Published in final edited form as: Biochemistry. 2007 Feb 13;46(10):2823–2830. doi: 10.1021/bi061309j

hTS inhibition by PDPA. The results are presented as a Lineweaver-Burke plot. (SigmaPlot v9.0.1) A) Versus dUMP. Error bars represent standard deviations based on five measurements for each point. Fig 3B) Versus the cosubstrate, CH₂H₄folate. The ratios of standard deviations to the rates are 0.013, 0.006, 0.032, 0.032, 0.018 for increasing concentrations of PDPA as shown in the inset. Numerical data are included as supplementary material.

hTS inhibition by PDPA. The results are presented as a Lineweaver-Burke plot. (SigmaPlot v9.0.1) A) Versus dUMP. Error bars represent standard deviations based on five measurements for each point. Fig 3B) Versus the cosubstrate, CH₂H₄folate. The ratios of standard deviations to the rates are 0.013, 0.006, 0.032, 0.032, 0.018 for increasing concentrations of PDPA as shown in the inset. Numerical data are included as supplementary material.