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Insulin/IGF-1R determine the proliferative potential of progenitor cells in vitro through the activation of the small GTPase Rac. (A) Colony-forming assay using dko primary keratinocytes transduced with either GFP lentivirus or RacDA lentivirus. (B) Quantification of size of colonies in colony formation assay. (C) Average number of cells in a colony. P<0.05.
