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Rac activation is necessary for epidermal morphogenesis in the IGF-1Repi−/− mice. (A) H&E staining of back skin (scale bar is 50 μm) and palate (scale bar is 100 μm) of IGF-1Repi−/− and IGF-1Repi−/− RacDA mice. (B, C) Quantification of thickness of epidermis (B, without stratum corneum) and palate (C) in IGF-1Repi−/− and IGF-1Repi−/−; RacDA mice. N=5 mice per genotype. P=0.02.
