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. 2008 Aug 26;3(8):e3065. doi: 10.1371/journal.pone.0003065

Figure 2. AKTi-1/2 inhibits Akt signaling and causes G1 arrest in PIK3CA-mutant but not in PIK3CA-WT breast cancer cells.

Figure 2

(A) HCC1806 and T47D cells were treated with 1 µM AKTi-1/2 for the indicated times and cell lysates were immunoblotted with the indicated antibodies. (B) HCC1806 and T47D cells were treated with 1 µM AKTi-1/2 or DMSO for 24 h. The fractions of cells in G1, S and G2/M were determined by flow cytometry.