Fig. 5.

Blood glucose response over 10 days with the corresponding basal infusion profile for case eight. The dotted line in the insulin plot indicates the optimal basal infusion profile. Initial basal rates are set according to the clinical heuristics, with segment one slightly underdosed, segment two is overdosed, segment three is very close to target, and segment four is underdosed. These settings result in periods of hyper- and hypoglycemia, with levels converging to clinically acceptable levels by the fifth day.