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Schematic diagram of the platelet-platelet bridging model that depicts two platelets transiently aggregating in linear shear flow via GPIbα-vWF-GPIbα bond formation. A single vWF molecule can bind several receptors on a single platelet. Each platelet is coated with a 50-nm incompressible surface roughness layer equal to the height of the GPIbα surface receptors. Components of the diagram are not drawn to scale.
