Table 2.

Differentially expressed apoptotic genes in NSCLC {Singhal, 2003 #191}.

A. GENES OVER-EXPRESSED IN PATIENTS WITH LUNG ADENOCARCINOMAS
Gene Symbol	Gene Name	Upregulated	p-value
BIRC5	Survivin	3.9	0.00154
AKT1	Akt	3.5	0.00873
MAP3K14	NIK (mitogen-activated protein kinase kinase kinase 14)	2.6	0.00382
BCL2L1	BcL-xL	2.1	0.01604
MDM2	MDM2	1.9	0.00212
CASP3	Caspase 3	1.6	0.02170
B. GENES DOWN-REGULATED IN PATIENTS WITH LUNG ADENOCARCINOMAS
Gene Symbol	Gene Name	Down-regulated	p-value
PRF1	Perforin	3.5	0.00001
CTLA1	Granzyme B	3.4	0.00856
AXUD1	Axud1	2.8	0.00011
S100A9	p14 (ARF, S100 calcium binding protein A9, calgranulin B)	2.2	0.00326
DAPK2	DAPK 2 (death-associated protein kinase 2)	2.1	0.00010
BAK1	BAK1	2.1	0.00376
PTEN	PTEN (phosphatase and tensin homolog)	1.9	0.00346
TNFRSF6	FAS (tumor necrosis factor receptor superfamily, member 6)	1.8	0.00023
MAP3K7	TAK 1 (mitogen-activated protein kinase kinase kinase 7)	1.8	0.00034
TNFRSF1A	TNF-alpha receptor	1.7	0.00225
CASP10	Caspase 10	1.7	0.00235
NFKBIA	IkappaB	1.7	0.00750
CDKN2D	p19 (cyclin-dependent kinase inhibitor 2D, inhibits CDK4)	1.6	0.00336
C. APOPTOSIS GENES WITH ALTERED GENE EXPRESSION NOT PREVIOUSLY REPORTED IN NSCLC
Gene Symbol	Gene Name	Upregulated	p-value
PDPK1	PDK1 (3-phosphoinositide dependent protein kinase-1)	2.2	0.00461
Gene Symbol	Gene Name	Down-regulated	p-value
RIPK1	RIP (Receptor interacting protein)	2.7	0.00038
MAP3K6	MAPKKK6 (mitogen-activated protein kinase kinase kinase 6)	2.2	0.00061
CASP1	Caspase 1	2.1	0.00053
CASP5	Caspase 5	2.0	0.00031
CYCS	Cytochrome c	1.9	0.00004
CASP2	Caspase 2	1.8	0.00004
CRADD	RAIDD	1.8	0.00070
CASP9	Caspase 9	1.7	0.00045
APAF1	Apaf-1 (apoptotic protease activating factor)	1.6	0.00035