Table 1.

Voxelwise correlational analyses of the effect of COMT val¹⁵⁸met genotype upon high g_f − low g_f neural activity

Brain regions	Coordinatesa	Z score	Pb	rc	rpd
Spatial task
Right DLPFC	42, 24, 27	3.62	P < 0.005	0.70	0.60
ACC	−9, 27, 21	3.43	P < 0.01	0.67	0.65
Pre-SMA	9, 24, 42	3.32	P < 0.02	0.66	0.59
Left IPS	−33, −51, 33	3.04	P < 0.05	0.61	0.54
Right IPS	39, −60, 33	3.27	P < 0.02	0.65	0.63
Verbal task
Left DLPFC	−36, 24, 18	2.70	P  = 0.065	0.56	0.52
Right DLPFC	39, 27, 24	3.37	P < 0.02	0.66	0.64
Left FO/AI	−27, 15, 3	2.96	P < 0.05	0.60	0.55
Right FO/AI	30, 18, 6	3.28	P < 0.02	0.65	0.69
Pre-SMA	−9, 18, 42	3.52	P < 0.01	0.69	0.37
Left IPS	−36, −45, 36	3.77	P < 0.005	0.72	0.69
Right IPS	36, −57, 48	3.10	P < 0.05	0.62	0.59

Note: The number of COMT val alleles possessed (0–2) was correlated against high g_f − low g_f neural activity on a voxel by voxel basis within each ROI.

^aCorrelation peak coordinates. Peaks are reported for each ROI where one or more voxels showed a significant or near significant (P < 0.1) correlation between number of COMT val alleles possessed and high g_f − low g_f neural activity after small volume correction for multiple comparisons.

^bP value after small volume correction.

^cCorrelation at peak voxel.

^dPartial correlation at peak voxel after controlling for high g_f behavioral performance (all reported partial correlations are significant at least at P < 0.05 uncorrected).