Table 2.

ROI-composite correlational analyses of the effect of COMT val¹⁵⁸met genotype upon high g_f − low g_f neural activity

Neural ROI (region, ROI centre point)a	Z score	Significance (P)
Spatial task
Left DLPFC (−42, 24, 24)	0.94	P > 0.1
Right DLPFC (42, 24, 24)	3.11	P < 0.001b
Left FO/AI (−36, 18, 0)	0.97	P > 0.1
Right FO/AI (36, 18, 0)	0.88	P > 0.1
ACC (0, 30, 21)	2.22	P < 0.02
Pre-SMA (0, 21, 45)	2.66	P < 0.005c
Left IPS (−36, −54, 39)	2.68	P < 0.005c
Right IPS (36, −54, 39)	2.69	P < 0.005c
Verbal task
Left DLPFC (−42, 24, 24)	2.46	P < 0.01
Right DLPFC (42, 24, 24)	2.60	P < 0.005c
Left FO/AI (−36, 18, 0)	2.31	P < 0.01
Right FO/AI (36, 18, 0)	2.75	P < 0.003c
ACC (0, 30, 21)	1.39	P  = 0.08
Pre-SMA (0, 21, 45)	2.65	P < 0.005c
Left IPS (−36, −54, 39)	2.83	P < 0.005c
Right IPS (36, −54, 39)	2.75	P < 0.005c

Note: For each ROI, the number of COMT val alleles possessed (0–2) was correlated against high g_f − low g_f neural activity using a composite measure of activation extracted from and averaged across all voxels within the ROI.

^aAll ROIs were 10-mm radius spheres.

^bSignificant at P < 0.01 when corrected for number of ROIs examined.

^cSignificant at P < 0.05 when corrected for number of ROIs examined.