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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Heart Rhythm. 2008 Mar 21;5(7):1019–1026. doi: 10.1016/j.hrthm.2008.03.018

Figure 5.

Figure 5

Ranolazine suppresses delayed afterdepolarizations (DADs) and triggered activity (TA) induced by isoproterenol in a PV sleeve preparation. Upper panel: effect of isoproterenol (1 µM). DAD activity is apparent following a train of 20 beats at basic cycle length (BCL) of 200 ms, and increases in amplitude as BCL is reduced to 150 and 120 ms. The DAD reaches threshold as the train was extended to 35 beats, giving rise to a triggered beat (arrow) followed by a small DAD. Lower panel: ranolazine abolished the DAD and DAD-induced TA.