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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Heart Rhythm. 2008 Mar 21;5(7):1019–1026. doi: 10.1016/j.hrthm.2008.03.018

Figure 7.

Figure 7

Ranolazine abolishes late phase 3 EADs and triggered activity (TA) induced by ACh and high calcium ([Ca2+]o = 5.4 mM) in a PV sleeve preparation. Basic cycle length (BCL) = 1000 ms. A. control. B. ACh/high calcium induced late phase 3 EADs (first 2 beats) and late-phase 3 EAD-induced triggered activity (TA) (third beat). C. Ranolazine (10 µM) abolished late phase 3 EADs and TA. D. Upon washout of ranolazine (30 minutes), late phase 3 EADs and TA reappear.