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Relationship between overall peptide charge and activity on the NPR-1 receptor. The overall peptide charge at neutral pH is plotted against activity for all of the peptides analyzed in this study. For the linear fit, R2 = 0.67. Legend: Filled circle = 4, Open Circle = 2, Filled Square = 9, Open Square = 5, Filled Triangle = 6, Open Triangle = 7, Filled Diamond = 1, Open Diamond = 10, Filled Hexagon = 11, Open Hexagon = 12 (numbers correspond to peptide numbers in Table 2)
