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. Author manuscript; available in PMC: 2009 Jun 23.
Published in final edited form as: Neuroscience. 2008 Mar 29;154(2):653–666. doi: 10.1016/j.neuroscience.2008.03.049

Figure 2.

Figure 2

Histograms summarizing the distribution of mGluR1a and mGluR5 immunoperoxidase labeling in saline- and cocaine-treated rats, expressed as mean density of labeled elements per 100μm2 (±SEM). (A–B) Immunoperoxidase labeling for mGluR1a and mGluR5 in the core and shell of the nucleus accumbens 45 minutes following a saline or cocaine injection. Total number of animals and labeled elements: mGluR1a: saline, core=4, 552; saline, shell=4, 470; cocaine, core=5, 822; cocaine, shell=5, 784. mGluR5: saline, core=5, 1012; saline, shell=5, 807; cocaine, core=5, 882; cocaine, shell=5, 729. (C–D) Immunoperoxidase labeling for mGluR1a and mGluR5 24 hours following saline or cocaine. Total number of animals and labeled elements: mGluR1a: saline, core=5, 786; saline, shell=4, 473; cocaine, core=5, 672; cocaine, shell=5, 643. mGluR5: saline, core=4, 831; saline, shell=4,710; cocaine, core=5, 1053; cocaine, shell=5, 694. (E–F) Immunoperoxidase labeling for mGluR1a and mGluR5 3 weeks following one-week chronic saline or cocaine. Total number of animals and labeled elements: mGluR1a: saline, core=7, 1682; saline, shell=7, 1381; cocaine, core=7, 1770; cocaine, shell=7, 1365. mGluR5: saline, core=7, 1897; saline, shell=7, 1471; cocaine, core=7, 1939; cocaine, shell=7, 1882. Abbreviations: Un. Axons: Unmyelinated axons; My. Axons: Myelinated axons; AT: Axon terminals.