Table 1.
Subsynaptic group I mGluRs labeling after cocaine treatment in the accumbens core. Data are presented as percent of gold particles ±SEM for each subsynaptic domain in Spines, Sm. Den (small dendrites) and Lg. Den (large dendrites). The different categories of subsynaptic domains are abbreviated as follows: Extra= extrasynaptic; Peri-Asym=perisynaptic labeling to asymmetric synapses; Syn-Asym=synaptic labeling of asymmetric synapses; Peri-Symm=perisynaptic labeling at symmetric synapses; Syn-Symm=synaptic labeling at symmetric synapses. Data for mGluR1a are in the top row of each box, while mGluR5 data are in the bottom row of each box. The number of animals used, elements examined and gold particles counted is presented in the legend of figure 4.
| Acute Cocaine-
45 MINUTES |
Acute Cocaine-
24 HOURS |
Chronic Cocaine | ||||
|---|---|---|---|---|---|---|
| MGluR1a | Saline-Core | Cocaine-Core | Saline-Core | Cocaine-Core | Saline-Core | Cocaine-Core |
| mGluR5 | ||||||
| SPINES Extra | 78.7±4.5 | 79.8±6.1 | 85.3±2.3 | 81.0±1.2 | 82.6±1.3 | 86.8±1.5 |
| 84.3±3.5 | 83.8±2.1 | 82.7±7.4 | 83.2±2.2 | 83.1±1.3 | 82.2±1.3 | |
| Peri-Asym | 18.3±3.4 | 20.2±6.1 | 14.5±2.1 | 18.2±1.4 | 14.8±0.7 | 12.5±1.4 |
| 14.9±1.7 | 16.0±2.1 | 18.9±5.5 | 14.8±2.3 | 14.6±1.9 | 16.2±1.7 | |
| Syn-Asym | 2.9±1.4 | 0 | 0.3±0.3 | 0.2±0.2 | 1.6±0.7 | 0.7±0.3 |
| 0.8±0.6 | 0.2±0.2 | 1.4±0.7 | 1.7±0.5 | 1.1±0.3 | 1.1±0.4 | |
| Peri-Symm | 0 | 0 | 0 | 0.6±0.6 | 1.3±0.6 | 0 |
| 0 | 0 | 0.4±0.4 | 0.3±0.3 | 1.1±0.4 | 0 | |
| Syn-Symm | 0 | 0 | 0 | 0 | 0 | 0 |
| 0 | 0 | 0 | 0 | 0.2±0.2 | 0.3±0.3 | |
| SM. DEN Extra | 98.1±1.2 | 96.3±1.7 | 97.6±0.8 | 96.2±0.7 | 97.3±0.9 | 98.5±1.0 |
| 98.5±0.5 | 97.3±1.4 | 97.9±0.7 | 98.3±0.6 | 98.5±0.6 | 98.0±0.4 | |
| Peri-Asym | 0.3±0.3 | 1.8±1.2 | 1.1±0.5 | 0.7±0.3 | 0.9±0.2 | 1.5±0.2 |
| 0.4±0.2 | 0.7±0.3 | 1.3±0.7 | 0.4±0.2 | 0.4±0.2 | 0.9±0.4 | |
| Syn-Asym | 0.3±0.3 | 0 | 0.2±0.1 | 0.3±0.2 | 0.1±0.1 | 0±0.1 |
| 0.1±0.1 | 0.3±0.3 | 0.4±0.4 | 0 | 0.2±0.2 | 0.1±0.1 | |
| Peri-Symm | 1.4±0.8 | 1.9±1.1 | 0.7±0.3 | 1.3±0.4 | 1.7±0.9 | 0±0.6 |
| 0.8±0.3 | 1.3±1.0 | 0.2±0.1 | 0.7±0.3 | 0.7±0.2 | 1.0±0.3 | |
| Syn-Symm | 0 | 0 | 0.5±0.2 | 1.6±0.6 | 0.1±0.1 | 1.0±0.5 |
| 0.2±0.1 | 0.5±0.5 | 0.1±0.1 | 0.7±0.3 | 0.1±0.1 | 0.1±0.0 | |
| LG. DEN Extra | 97.5±1.6 | 96.1±2.9 | 96.4±1.5 | 94.9±3.4 | 96.0±1.5 | 96.5±1.7 |
| 94.2±3.3 | 97.3±1.7 | 100±0 | 96.4±2.3 | 96.7±2.3 | 96.1±1.5 | |
| Peri-Asym | 0 | 0 | 1.9±1.2 | 2.4±2.4 | 0 | 0 |
| 1.4±1.4 | 0.8±0.8 | 0 | 1.4±0.9 | 0.9±0.9 | 2.2±1.3 | |
| Syn-Asym | 0 | 0 | 0.3±0.3 | 0 | 0 | 0 |
| 0 | 0 | 0 | 0 | 0 | 0 | |
| Peri-Symm | 2.4±1.5 | 2.2±2.2 | 0.8±0.8 | 1.6±1.6 | 4.0±1.5 | 3.0±1.8 |
| 1.8±1.1 | 0.8±0.8 | 0 | 0.4±0.4 | 2.3±2.3 | 1.8±1.0 | |
| Syn-Symm | 0 | 1.7±1.0 | 0.7±0.4 | 1.2±1.2 | 0 | 0.5±0.5 |
| 1.8±1.4 | 1.2±1.2 | 0 | 1.9±1.9 | 0 | 0 | |