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. Author manuscript; available in PMC: 2008 Aug 18.
Published in final edited form as: Neuropharmacology. 2006 Dec 14;52(3):1044–1054. doi: 10.1016/j.neuropharm.2006.11.001

Table 2.

Anticonvulsant activity in 6 Hz psychomotor seizure test in mice. Values shown in brackets represent 95% confidence intervals

ED50 (mg/kg) TD50 (mg/kg) T.I. T.P.E. (hours)
DPH 27.5 (16.3 – 45.5)† 35.6 (25.6 – 48.9)† 1.3† 1
HA 47.1 (26.5 – 68.9) 131 (117 – 148) 2.8 0.5
†

The significant toxicity observed at doses of ≥ 50 mg/kg, i.p. precluded accurate determination of an ED50 value for phenytoin in this model. Based on the results up to 50mg/kg, an estimated ED50 value and protective index (PI) have been calculated for phenytoin (DPH) using Probit software.