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. 2008 Apr 17;586(Pt 12):2841–2853. doi: 10.1113/jphysiol.2008.151027

Figure 5. Creatine enhances myonuclear addition through a CK-dependent mechanism.

Figure 5

A, myoblasts containing siRNA for CKB and CKM or a control siRNA were differentiated for 42–46 h. Myotube lysates were analysed for creatine kinase (CK) activity. Data are means from two independent experiments. B, representative images of siRNA containing cells following differentiation for 48 h in the absence (–CRT) and presence of 12.5 mm creatine (+CRT) are shown. Bar: 100 μm. C, following creatine treatment myonuclear number was decreased in cells containing siRNA for CK. Data are means ±s.e.m. from three independent experiments.