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. 2008 Apr 25;586(Pt 12):2827–2840. doi: 10.1113/jphysiol.2007.148601

Figure 2. KCNQ3 TCC2 is a negative regulator of current expression in the absence of KCNQ2 TCC2.

Figure 2

A, representative current traces for KCNQ2/KCNQ3 (upper left), KCNQ2ΔTCC2/KCNQ3 (bottom left), KCNQ2/KCNQ3ΔTCC2 (upper right) and KCNQ2ΔTCC2/KCNQ3ΔTCC2 (bottom right) channels. B, multiple comparisons of maximum tail current amplitudes obtained with wild-type channels and TCC2-deletion mutants. *P < 0.05, **P < 0.01 and ***P < 0.001 (Tukey's test). C, whole and surface expression levels for TCC2-deletion mutants in oocytes. Total KCNQ2 represents KCNQ2 proteins from whole cell lysate to confirm the even expression levels for wild-type and TCC2-deletion channels. Surface KCNQ2 represents surface KCNQ2 proteins which were biotinylated before sonication (see Methods).