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. Author manuscript; available in PMC: 2009 Jul 1.
Published in final edited form as: Am J Cardiol. 2008 May 9;102(1):47–53. doi: 10.1016/j.amjcard.2008.02.095

Table 3. Chronic kidney disease and the risk of incident cardiovascular disease, coronary heart disease and mortality among Framingham Heart Study Offspring Participants.

CVD p-value CHD p-value All-cause mortality p-value CVD-mortality p-value
Chronic Kidney Disease*
Age and sex 1.19(1.02-1.40) 0.03 1.23(1.02-1.48) 0.03 1.24(1.06-1.45) 0.01 1.39(1.08-1.79) 0.01
Multivariable 1.17(0.99-1.38) 0.06 1.21(1.00-1.50) 0.05 1.14(0.96-1.34) 0.13 1.27(0.98-1.64) 0.08
Stage3a Chronic Kidney Disease**
Age and Sex 1.10(0.92-1.32) 0.31 1.17(0.95-1.44) 0.13 1.14(0.95-1.37) 0.15 1.32(0.99-1.75) 0.06
Multivariable 1.08(0.90-1.30) 0.42 1.17(0.94-1.44) 0.16 1.06(0.88-1.28) 0.53 1.24(0.92-1.66) 0.16
Stage 3b Chronic Kidney Disease†
Age and Sex 1.50(1.12-2.01) 0.007 1.39(0.98-1.97) 0.07 1.37(1.05-1.80) 0.02 1.50(0.96-2.32) 0.07
Multivariable 1.41(1.05-1.91) 0.02 1.31(0.91-1.86) 0.14 1.20(0.90-1.59) 0.21 1.29(0.82-2.01) 0.27

CVD=cardiovascular

Multivariable models adjusted for age, sex, body mass index, total/HDL cholesterol, smoking, diabetes, hypertension treatment and systolic blood pressure

Mortality and CVD mortality follow-up truncated at ten-years

*

GFR < 59 mL/min per 1.73 m2 in women and < 64 mL/min per 1.73 m2 in men

**

GFR 45 to <59 mL/min per 1.73 m2 in women and 51 to <64 mL/min per 1.73 m2 in men

†

GFR 30-44 mL/min per 1.73 m2 in women and 30-50 mL/min per 1.73 m2 in men