Table 1.

Mean (±SD) body weight changes, and relative liver and kidney weights of female Hanover Wistar rats treated with carbon tetrachloride (CCl₄) at dose levels from 0.4 to 1.0 ml/kg twice weekly for 6 weeks, and at week 12 following a 6-week recovery period without dosing^†

		Dose of CCl4 (ml/kg)
	Week	0 (control)	0.4	0.5	0.6	0.7	0.8	0.9	1.0
Body weight§ (g)	0‡	185.17 ± 17.68	164.67 ± 10.67	174.67 ± 21.69	166.50 ± 6.98	172.67 ± 5.39	177.00 ± 14.87	177.67 ± 9.31	178.83 ± 7.88
	6	234.00 ± 23.19	194.67 ± 14.90	203.67 ± 26.79	193.83 ± 11.11	200.33 ± 5.82	202.83 ± 16.25	200.83 ± 12.53	201.50 ± 9.14
	12	242.33 ± 21.87	216.33 ± 16.81	228.83 ± 34.20	218.67 ± 9.99	225.50 ± 5.79	232.50 ± 17.63	231.00 ± 14.67	225.00 ± 7.51
Relative liver weight(g/kg body weight)	6	35.89 ± 1.93	44.68*** ± 2.17	44.57*** ± 3.70	46.91*** ± 3.10	51.33*** ± 4.63	50.12*** ± 5.09	46.95*** ± 2.93	54.64*** ± 5.78
	12	24.30 ± 2.82	26.03 ± 0.79	26.93 ± 1.47	27.06 ± 1.30	27.38* ± 1.31	28.02* ± 1.80	27.34 ± 2.52	26.59 ± 1.24
Relative kidney weight¶(g/kg body weight)	6	2.88 ± 0.15	3.15** ± 0.14	3.08* ± 0.15	3.26* ± 0.29	3.36** ± 0.31	3.2* ± 0.22	3.15* ± 0.25	3.50*** ± 0.24
	12	2.67 ± 0.16	2.67 ± 0.16	2.71 ± 0.15	2.77 ± 0.14	2.82 ± 0.17	2.75 ± 0.17	2.73 ± 0.08	2.71 ± 0.18

^†Rats were treated with CCl₄ by gavage. *Significantly different from control at the same time point P < 0.05, **P < 0.01, ***P < 0.001. n = 6 rats per dose level group at each time point.

^‡Body weight at the time of administration of the first dose of CCl₄.

^§Body weight data were not analysed statistically.

^¶Mean weight of left and right kidney.